Alzheimer's disease (NCD)

The full DSM-5-TR criteria are not included in this record. Everything the record does hold is shown below. Check DSM-5-TR before recording the diagnosis.

1. A

   Key feature A

   Criteria met for major or mild NCD (substantial or modest cognitive decline in ≥1 domain)

2. B

   Key feature B

   Insidious onset and gradual progression in ≥1 cognitive domain (most often episodic memory early)

3. C

   Key feature C

   Probable AD: genetic mutation or ≥2 declining domains + no mixed aetiology; Possible AD: no genetic evidence or insufficient domains or mixed aetiology present

4. D

   Key feature D

   Disturbance not better explained by cerebrovascular disease, another NCD, medical condition, or substances

Mild NCD due to AD

Modest cognitive decline; independence in everyday activities preserved.

Major NCD due to AD

Substantial cognitive decline; interferes with independence in everyday activities.

With behavioural disturbance

Agitation, aggression, psychosis, apathy, or disinhibition present.

Early onset

Onset before age 65.

Late onset

Onset at age 65 or older.

Probable Alzheimer's disease

Clear genetic or biomarker evidence, or gradual progressive course with two documented cognitive domains.

Possible Alzheimer's disease

Typical clinical presentation without biomarker confirmation or atypical course without alternative explanation.