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Fat-Soluble·Vitamins & Minerals
Prevention and treatment of Vitamin A deficiency, fat-malabsorption syndromes (CF, post-bariatric surgery), measles in pediatrics
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Max Dose
3000 mcg RE/day
Half-life
Months
High risk: Teratogenic
CRITICAL
High risk: Toxicity
HEPATIC/CNS
Avoid / Cautions
Hypervitaminosis A, concurrent use of systemic retinoids (Roaccutane/Isotretinoin). Pregnancy Category D (at doses > 10,000 IU). Causes severe craniofacial and cardiac birth defects.
Overview
Essential fat-soluble vitamin. Crucial for vision (rhodopsin synthesis), immune function, and cellular differentiation. Stored in massive quantities in the liver.
Clinical Focus
Highly teratogenic in excess. Pregnant women MUST avoid high-dose supplements and liver pate/liver meats.
Bottom Line
Vitamin A is essential for vision, immunity, and skin health, but is teratogenic in high doses during pregnancy and chronic excess causes hepatotoxicity.
Brand Names
Various OTC brands
Oral Routes
Capsules/Tablets. Usually formulated as Retinol or Beta-carotene.
Prescribing & PBS
Over The Counter (OTC).
Primary
Prevention and treatment of Vitamin A deficiency, fat-malabsorption syndromes (CF, post-bariatric surgery), measles in pediatrics.
Clinical Place
Deficiency is rare in Australia outside of severe malabsorption/alcoholism. Systemic retinoids (Isotretinoin) are used for acne.
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