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Stimulant Laxative·Gastrointestinal - Laxatives
Opioid-induced constipation, acute severe constipation
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Max Dose
4 tabs/day
Onset
6-12 h
Caution: Cramping
COMMON
Caution: Melanosis Coli
CHRONIC USE
Avoid / Cautions
Intestinal obstruction, undiagnosed severe abdominal pain, inflammatory bowel disease flares. Pregnancy Category A, but strong stimulants can theoretically trigger uterine contractions. Osmotics (Lactulose/Movicol) are preferred.
Overview
Plant-based anthraquinone stimulant laxative. Directly irritates the bowel to force peristalsis. The ultimate 'push' laxative.
Clinical Focus
Indispensable for opioid-induced constipation. Must be given at night so the bowel moves in the morning.
Bottom Line
Senna is a cheap and effective stimulant laxative for opioid-induced and simple constipation, but causes abdominal cramping and should not be used long-term due to dependence risk.
Brand Names
Senokot, Coloxyl with Senna (combo)
Oral Routes
Tablets (7.5 mg sennosides).
Prescribing & PBS
Over The Counter (OTC).
Primary
Opioid-induced constipation, acute severe constipation.
Clinical Place
Opioids paralyze the gut. You cannot just use a softener; you MUST use a stimulant (Senna) to force the paralyzed bowel to move.
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