FGA / Phenothiazine·Psychiatry - Oral Antipsychotics

Periciazine

Schizophrenia, acute severe behavioral disturbances, severe impulsivity/aggression

PBSLOW-POTENCY FGANeulactil2.5 mg tabletS4+1

No source link confirmed for this record yet. Its own source notes are under Additional.

At a glance

Max Dose

75 mg/day

Half-life

10-20 h

Caution: Sedation

SEVERE

Caution: Orthostasis

HIGH RISK

Cautions

Avoid / Cautions

Severe CNS depression, narrow-angle glaucoma, severe cardiac failure.

Where it stands

Rapid Summary

Overview

Low-potency phenothiazine. Heavily sedating. Primarily used for acute behavioral disturbances and severe insomnia in psychiatric settings rather than as a primary antipsychotic.

Clinical Focus

High risk of orthostatic hypotension and anticholinergic delirium in the elderly. Often prescribed inappropriately as a 'sleeping pill'.

Bottom Line

Periciazine is a low-potency phenothiazine antipsychotic used for behavioural disturbance, but causes significant sedation and anticholinergic effects with limited antipsychotic efficacy.

Formulation & Access

Brand Names

Neulactil

Oral Routes

Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL).

Prescribing & PBS

Unrestricted General Benefit (S4).

Indications & Use

Primary

PBSTGA

Schizophrenia, acute severe behavioral disturbances, severe impulsivity/aggression.

Clinical Place

A common oral 'rescue' or PRN medication on psychiatric wards to settle agitated patients without needing injections.

Quick reference

Class & Role

FGA / Phenothiazine — Low-potency phenothiazine.

Route / Formulation

Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL). (Neulactil)

Usual Dose & Max

PO 10-20 mg BD to TDS. Max 75 mg/day.

Key Indication Doses

Severe Behavioral Disturbance / Aggression: PO 10-20 mg BD to TDS. Max 75 mg/day. Agitation (Elderly): Start at 2.5 mg. Increase to max 10 mg/day strictly under supervision. Insomnia (Off-Label): PO 2.5-10 mg NOCTE.

Best Uses

Periciazine is a low-potency phenothiazine antipsychotic used for behavioural disturbance, but causes significant sedation and anticholinergic effects with limited antipsychotic efficacy.

Key Risks

Neurological: Profound sedation, hangover, EPS (less than high-potency FGAs like Haldol, but still present). Cardiovascular: Orthostatic hypotension, tachycardia, QTc prolongation. Gastrointestinal: Dry mouth, constipation (Anticholinergic toxidrome).

Key Interactions

Additive hypotension and sedation with antihypertensives, Opioids, and Benzos.

Monitoring

Monitor lying and standing BP. Implement falls precautions.

Clinical Pearl

Because it is so sedating, doctors often write Periciazine 10mg PRN for sleep. In the elderly, this causes massive morning hypotension, anticholinergic confusion, and fractured hips. Use a safer alternative (like low-dose Mirtazapine or Temazepam) if possible.

Access

Neulactil2.5 mg tablet

Brand: Neulactil
Formulation: Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL).

From this page

No calculator, monitoring schedule or factsheet is linked to this medicine page yet.

FGA / Phenothiazine·Psychiatry - Oral Antipsychotics

Periciazine

Schizophrenia, acute severe behavioral disturbances, severe impulsivity/aggression

PBSLOW-POTENCY FGANeulactil2.5 mg tabletS4+1

No source link confirmed for this record yet. Its own source notes are under Additional.

At a glance

Max Dose

75 mg/day

Half-life

10-20 h

Caution: Sedation

SEVERE

Caution: Orthostasis

HIGH RISK

Cautions

Avoid / Cautions

Severe CNS depression, narrow-angle glaucoma, severe cardiac failure.

Where it stands

Rapid Summary

Overview

Low-potency phenothiazine. Heavily sedating. Primarily used for acute behavioral disturbances and severe insomnia in psychiatric settings rather than as a primary antipsychotic.

Clinical Focus

High risk of orthostatic hypotension and anticholinergic delirium in the elderly. Often prescribed inappropriately as a 'sleeping pill'.

Bottom Line

Periciazine is a low-potency phenothiazine antipsychotic used for behavioural disturbance, but causes significant sedation and anticholinergic effects with limited antipsychotic efficacy.

Formulation & Access

Brand Names

Neulactil

Oral Routes

Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL).

Prescribing & PBS

Unrestricted General Benefit (S4).

Indications & Use

Primary

PBSTGA

Schizophrenia, acute severe behavioral disturbances, severe impulsivity/aggression.

Clinical Place

A common oral 'rescue' or PRN medication on psychiatric wards to settle agitated patients without needing injections.

Quick reference

Class & Role

FGA / Phenothiazine — Low-potency phenothiazine.

Route / Formulation

Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL). (Neulactil)

Usual Dose & Max

PO 10-20 mg BD to TDS. Max 75 mg/day.

Key Indication Doses

Best Uses

Periciazine is a low-potency phenothiazine antipsychotic used for behavioural disturbance, but causes significant sedation and anticholinergic effects with limited antipsychotic efficacy.

Key Risks

Key Interactions

Additive hypotension and sedation with antihypertensives, Opioids, and Benzos.

Monitoring

Monitor lying and standing BP. Implement falls precautions.

Clinical Pearl

Access

Neulactil2.5 mg tablet

Brand: Neulactil
Formulation: Tablets (2.5 mg, 10 mg). Oral liquid drops (10 mg/mL).

From this page

No calculator, monitoring schedule or factsheet is linked to this medicine page yet.