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Progestin·Endocrinology - Women's Health
Long-term contraception, heavy menstrual bleeding, endometriosis, endometrial protection in HRT
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Max Dose
150 mg/12W (IM)
Half-life
50 DAYS (IM)
High risk: Bone Loss
BLACK BOX
Caution: Weight Gain
HIGH RISK
Avoid / Cautions
Pregnancy, unexplained vaginal bleeding, active/suspected breast cancer, severe liver disease, thromboembolic disease history, and major osteoporosis risk need review. Depot use can reduce BMD and delay return to fertility.
Overview
Highly potent synthetic progestin. Most famously used as a 3-monthly contraceptive injection (Depo-Provera). Also used orally for menstrual regulation and endometriosis.
Clinical Focus
Depot medroxyprogesterone can reduce bone mineral density; reassess long-term use, especially in adolescents or osteoporosis risk. Delayed return to fertility is common after stopping.
Bottom Line
Medroxyprogesterone is a progestogen used for contraception (depot injection) and HRT, but the depot form causes significant bone density loss and delayed return of fertility.
Brand Names
Depo-Provera (IM), Provera (Oral), Ralovera
Parenteral
Vials/Pre-filled syringes (150 mg/1 mL) for deep IM or SC injection.
Oral Routes
Tablets (2.5, 5, 10, 100 mg).
Prescribing & PBS
Unrestricted General Benefit (S4).
Primary
Long-term contraception, heavy menstrual bleeding, endometriosis, endometrial protection in HRT.
Clinical Place
The definitive 'forget-proof' contraceptive injection. Often stops periods entirely (amenorrhea) after the first few doses.
No calculator, monitoring schedule or factsheet is linked to this medicine page yet.