Thiazide-like Diuretic·Cardiovascular - Diuretics

Indapamide

Hypertension

PBSDIURETICNatrilix, Natrilix SR, Coversyl Plus (combo)2.5 mg tabletS4+1

No source link confirmed for this record yet. Its own source notes are under Additional.

At a glance

Max Dose

2.5 mg/day

Half-life

14–24 h

High risk: Hyponatremia

RISK

BP Efficacy

HIGH

Cautions

Avoid / Cautions

Severe hepatic failure (can precipitate hepatic encephalopathy), anuria, severe sulfa allergy. Pregnancy Category C.

Where it stands

Rapid Summary

Overview

Thiazide-like diuretic. Superior to hydrochlorothiazide for blood pressure lowering with slightly less metabolic disruption (glucose/lipids).

Clinical Focus

Preferred over HCTZ in patients with metabolic syndrome or diabetes due to neutrality on glucose tolerance.

Bottom Line

Indapamide is a thiazide-like diuretic with superior stroke prevention evidence (ADVANCE, HYVET), but carries the same electrolyte disturbance risks as conventional thiazides.

Formulation & Access

Brand Names

Natrilix, Natrilix SR, Coversyl Plus (combo)

Oral Routes

Tablets IR (2.5 mg), Tablets SR (1.5 mg).

Prescribing & PBS

Unrestricted General Benefit (S4).

Indications & Use

Primary

PBSTGA

Hypertension.

Clinical Place

First-line diuretic option for hypertension. Supported by strong evidence in the elderly (HYVET trial).

Quick reference

Class & Role

Thiazide-like Diuretic — Thiazide-like diuretic.

Route / Formulation

Tablets IR (2.5 mg), Tablets SR (1.5 mg). (Natrilix, Natrilix SR, Coversyl Plus (combo))

Usual Dose & Max

PO 1.25-2.5 mg (IR) OD morning. OR PO 1.5 mg (SR) OD morning. Max 2.5 mg/day (IR) or 1.5 mg/day (SR).

Key Indication Doses

Hypertension: PO 1.25-2.5 mg (IR) OD morning. OR PO 1.5 mg (SR) OD morning. Elderly / Frail: Prefer 1.5 mg SR OD to minimise rapid electrolyte shifts.

Best Uses

Indapamide is a thiazide-like diuretic with superior stroke prevention evidence (ADVANCE, HYVET), but carries the same electrolyte disturbance risks as conventional thiazides.

Key Risks

Electrolytes: Severe hyponatremia and hypokalemia. Metabolic: Mildly increases uric acid (gout risk), but largely neutral regarding blood glucose and lipids (unlike HCTZ). Dermatological: Sulfa-allergy cross-reactivity, rare rash.

Key Interactions

Lithium (decreases clearance, high toxicity risk). NSAIDs + ACEi + Indapamide.

Monitoring

Check U&E within 1-2 weeks of initiation. Elderly women are at massive risk of silent hyponatremia. Monitor BP.

Clinical Pearl

If a hypertensive patient has pre-diabetes or hyperlipidemia, switch them from HCTZ to Indapamide to protect their metabolic profile.

Access

Natrilix, Natrilix SR, Coversyl Plus (combo)2.5 mg tablet

Brand: Natrilix, Natrilix SR, Coversyl Plus (combo)
Formulation: Tablets IR (2.5 mg), Tablets SR (1.5 mg).

From this page

No calculator, monitoring schedule or factsheet is linked to this medicine page yet.

Thiazide-like Diuretic·Cardiovascular - Diuretics

Indapamide

Hypertension

PBSDIURETICNatrilix, Natrilix SR, Coversyl Plus (combo)2.5 mg tabletS4+1

No source link confirmed for this record yet. Its own source notes are under Additional.

At a glance

Max Dose

2.5 mg/day

Half-life

14–24 h

High risk: Hyponatremia

RISK

BP Efficacy

HIGH

Cautions

Avoid / Cautions

Severe hepatic failure (can precipitate hepatic encephalopathy), anuria, severe sulfa allergy. Pregnancy Category C.

Where it stands

Rapid Summary

Overview

Thiazide-like diuretic. Superior to hydrochlorothiazide for blood pressure lowering with slightly less metabolic disruption (glucose/lipids).

Clinical Focus

Preferred over HCTZ in patients with metabolic syndrome or diabetes due to neutrality on glucose tolerance.

Bottom Line

Indapamide is a thiazide-like diuretic with superior stroke prevention evidence (ADVANCE, HYVET), but carries the same electrolyte disturbance risks as conventional thiazides.

Formulation & Access

Brand Names

Natrilix, Natrilix SR, Coversyl Plus (combo)

Oral Routes

Tablets IR (2.5 mg), Tablets SR (1.5 mg).

Prescribing & PBS

Unrestricted General Benefit (S4).

Indications & Use

Primary

PBSTGA

Hypertension.

Clinical Place

First-line diuretic option for hypertension. Supported by strong evidence in the elderly (HYVET trial).

Quick reference

Class & Role

Thiazide-like Diuretic — Thiazide-like diuretic.

Route / Formulation

Tablets IR (2.5 mg), Tablets SR (1.5 mg). (Natrilix, Natrilix SR, Coversyl Plus (combo))

Usual Dose & Max

PO 1.25-2.5 mg (IR) OD morning. OR PO 1.5 mg (SR) OD morning. Max 2.5 mg/day (IR) or 1.5 mg/day (SR).

Key Indication Doses

Hypertension: PO 1.25-2.5 mg (IR) OD morning. OR PO 1.5 mg (SR) OD morning. Elderly / Frail: Prefer 1.5 mg SR OD to minimise rapid electrolyte shifts.

Best Uses

Indapamide is a thiazide-like diuretic with superior stroke prevention evidence (ADVANCE, HYVET), but carries the same electrolyte disturbance risks as conventional thiazides.

Key Risks

Key Interactions

Lithium (decreases clearance, high toxicity risk). NSAIDs + ACEi + Indapamide.

Monitoring

Check U&E within 1-2 weeks of initiation. Elderly women are at massive risk of silent hyponatremia. Monitor BP.

Clinical Pearl

If a hypertensive patient has pre-diabetes or hyperlipidemia, switch them from HCTZ to Indapamide to protect their metabolic profile.

Access

Natrilix, Natrilix SR, Coversyl Plus (combo)2.5 mg tablet

Brand: Natrilix, Natrilix SR, Coversyl Plus (combo)
Formulation: Tablets IR (2.5 mg), Tablets SR (1.5 mg).

From this page

No calculator, monitoring schedule or factsheet is linked to this medicine page yet.