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NSAID·Analgesia - Simple & NSAIDs
Inflammatory pain, dysmenorrhoea, fever, rheumatoid arthritis, osteoarthritis
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Max Dose
2400 mg/day
Half-life
2 h
Caution: GI Bleed
RISK
Caution: Renal Risk
MODERATE
Avoid / Cautions
Active peptic ulcer disease, severe heart failure (NYHA IV), severe renal impairment, NSAID-sensitive asthma. Pregnancy Category C. STRICTLY CONTRAINDICATED in the 3rd trimester (causes premature closure of the fetal ductus arteriosus and oligohydramnios).
Overview
Non-selective Non-Steroidal Anti-Inflammatory Drug (NSAID). Highly effective for inflammatory and musculoskeletal pain. Short half-life.
Clinical Focus
Avoid in patients with asthma, severe kidney disease, or active peptic ulcers.
Bottom Line
Ibuprofen is a widely available NSAID for pain, inflammation, and fever, but carries significant GI bleeding, cardiovascular, and renal risk especially in elderly and dehydrated patients.
Brand Names
Nurofen, Advil, Brufen
Oral Routes
Tablets/Capsules (200, 400 mg). Oral liquid (100 mg/5mL).
Parenteral
Ampoules for IV use (Rare, usually reserved for patent ductus arteriosus closure in neonates).
Prescribing & PBS
Over The Counter (OTC) for 200 mg. S4 for higher strengths/large packs.
Primary
Inflammatory pain, dysmenorrhoea, fever, rheumatoid arthritis, osteoarthritis.
Clinical Place
Second step on analgesic ladder. The most widely used NSAID due to a relatively fast onset and acceptable safety profile at low doses.
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