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Biphasic Insulin·Endocrinology - Insulins & Injectables
Type 1 and Type 2 Diabetes
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Max Dose
Titrated
Caution: Composition
Varies
Caution: Timing
STRICTLY BD
Caution: Cloudy
MUST MIX
Avoid / Cautions
Active hypoglycemia. IV administration. Pregnancy Category A.
Overview
Pre-mixed biphasic insulin. Uses Insulin Lispro as the rapid component, and Protamine Lispro as the slow component. Comes in different ratios depending on the patient's carb intake.
Clinical Focus
Mix 25 contains 25% fast insulin. Mix 50 contains 50% fast insulin. Mixing them up causes catastrophic hypos or massive hyperglycemia.
Bottom Line
Humalog Mix 25/50 is a biphasic insulin mix for patients needing simplified injection regimens, but limits dose flexibility compared to basal-bolus therapy and increases hypoglycaemia risk.
Brand Names
Humalog Mix 25, Humalog Mix 50
Parenteral
Pre-filled pens (100 U/mL). Cloudy white suspension. MUST BE ROLLED.
Prescribing & PBS
Authority Required (PBS).
Primary
Type 1 and Type 2 Diabetes.
Clinical Place
Alternative to NovoMix 30. Mix 50 is specifically used for patients who eat massive, high-carb meals and need a stronger immediate insulin hit.
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