Neuroleptic malignant syndrome (NMS)
Dopamine antagonist exposure (antipsychotic or antiemetic) and development of severe muscle rigidity and elevated temperature
Dopamine antagonist exposure (antipsychotic or antiemetic) and development of severe muscle rigidity and elevated temperature
≥3 of 12 catatonia symptoms: stupor; catalepsy; waxy flexibility; mutism; negativism; posturing; mannerism; stereotypy; agitation; grimacing; echolalia; echopraxia
Persistent deficits in social communication/interaction across multiple contexts (≥3 components: social-emotional reciprocity; nonverbal communicative behaviours; developing/maintaining relationships)
≥1 full manic episode (abnormally elevated/expansive/irritable mood + ↑energy, ≥7 days or any duration if hospitalised)
≥1 of: delusions; hallucinations; disorganised speech; grossly disorganised/catatonic behaviour
≥5 of 9 SIG-E-CAPS symptoms for ≥2 weeks; ≥1 must be depressed mood or anhedonia
Uninterrupted period of illness including a major mood episode (MDE or manic) concurrent with Schizophrenia Criterion A symptoms
≥2 of: delusions; hallucinations; disorganised speech; grossly disorganised/catatonic behaviour; negative symptoms — ≥1 must be delusions, hallucinations, or disorganised speech
Same symptom criteria as Schizophrenia (≥2 of the 5 symptom clusters; ≥1 must be delusions, hallucinations, or disorganised speech)