Acute psychosis, open
EmergentFearful, suspicious, internally preoccupied, command-driven pacing/guarding/aggression
- Akathisia
- Bipolar mania
- Delirium
- Stimulant intoxication
Compare likely causes and exclusion clues.
Start from a scenario
Time-critical differentials to exclude first.
Fearful, suspicious, internally preoccupied, command-driven pacing/guarding/aggression
Acute stressor, often without full syndromal illness
Inner restlessness, pacing, shifting, inability to sit still after antipsychotic/antiemetic/antidepressant
Slurred speech, ataxia, disinhibition, aggression, nystagmus
Tremor, sweating, anxiety, agitation, insomnia, seizures after cessation
Restriction with fear of weight gain, body image distortion, drive for thinness, low weight/rapid loss
Dry mouth, constipation, urinary retention, blurry vision, confusion, delirium, tachycardia, hot dry skin
Dizziness, insomnia, nausea, flu-like symptoms, "brain zaps"
Activation after antidepressant initiation, especially in latent bipolarity
Sedation, weight gain, EPSE, prolactin elevation, constipation, QT prolongation, sexual dysfunction, emotional blunting
Restriction due to sensory aversion, fear of choking/vomiting, or low interest in food (no body image concern)
Overload, communication failure, routine disruption, pain
Catatonia with psychosis, seizures, dyskinesia, autonomic instability
Anxiety, tremor, perceptual disturbance, insomnia, agitation, seizures
Sedation, ataxia, slurred speech, disinhibition, amnesia
Depression with agitation, irritability, racing thoughts
High-priority causes that need prompt work-up.
Oculogyric crisis, jaw spasm, torticollis, tongue spasm, opisthotonic posturing soon after dopamine blockade
Early response not yet meeting full PTSD criteria
Chronic irritability, low frustration tolerance, impulsive outbursts, emotional reactivity since youth
Paranoia, theft beliefs, jealousy, disinhibition, progressive cognitive decline
Literal answers, topic perseveration, concrete speech, unusual prosody
Abrupt dysregulation from sensory overload, change, uncertainty, social demand
Days-to-weeks progression, confusion, catatonia, seizure, dyskinesia, autonomic instability
Recurrent depression, early onset, family history, atypical features, antidepressant activation
Distinct episodes of elevated/expansive/irritable mood with altered sleep, activity, confidence
Psychosis in context of elevated/irritable mood, reduced need for sleep
Marked drop in sleep time with overactivity, feeling energised
Grandiose/persecutory delusions during clear mania/mixed activation
Brief auditory hallucinations or perceptual distortions during severe stress
Recurrent crises around attachment threat, splitting, intense anger, reassurance-seeking
Transient dissociation during intense interpersonal conflict, abandonment threat, overwhelming emotion
Psychotic commands (external, authoritative) vs dissociative (internal, part-like)
Lower-acuity differentials for structured comparison.
Sedation, weight gain, sexual dysfunction, tremor, akathisia, constipation, cognitive dulling
Heavy alcohol history, poor nutrition, anterograde memory problems, confabulation
Gradual recent-memory decline, repetition, disorientation, language problems
Chronic deceit, exploitation, aggression, remorselessness, rule violation
Lifelong social-communication differences, adaptive limitations, concrete style
Bluntness, literalness, rigidity, overload rather than manipulative intent
Lifelong social-communication differences, sensory sensitivity, restricted interests, routines
Marked withdrawal, mutism, slowing, loss of skills after overload/stress
Irritability, overfamiliarity, suspiciousness fluctuate with state change
Preoccupation with perceived defect in appearance, mirror checking, camouflaging, avoidance
Agitation driven by pain, infection, constipation, retention, delirium
Mutism, staring, refusal, immobility, posturing, profound reduction in intake
Missed doses, poor comprehension, inability to sequence regimen
Progressive failure in ADLs, medications, finances, navigation, hygiene
Reduced motivation, engagement, poor hygiene, low energy, social withdrawal
Fatigue, pain, heaviness, GI symptoms, sleep disruption within mood/anxiety syndrome
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