Why it fits
Agitation, tremor, clonus, hyperreflexia, diaphoresis, diarrhoea, fever after serotonergic combinations
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Agitation, tremor, clonus, hyperreflexia, diaphoresis, diarrhoea, fever after serotonergic combinations
Hyperthermia, autonomic instability, ICU-level illness. Caused by: SSRI/SNRI + MAOI, tramadol, linezolid, lithium, St John's wort.
Temporal association with antipsychotic initiation, dose change, or depot timing.
Separates the Medication Side Effects / Iatrogenic Toxicity / QT Risk group. It is not specific to Serotonin syndrome.
Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group — not specific to Serotonin syndrome
Rows marked “Whole group”: Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group — not specific to Serotonin syndrome
Agitation, tremor, clonus, hyperreflexia, diaphoresis, diarrhoea, fever after serotonergic combinations
Hyperthermia, autonomic instability, ICU-level illness. Caused by: SSRI/SNRI + MAOI, tramadol, linezolid, lithium, St John's wort.
Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group.
Temporal association with antipsychotic initiation, dose change, or depot timing.
Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group.
Constipation with clozapine is a red flag, not a nuisance side effect Clozapine constipation and myocarditis are high-risk problems Escalate early, review bowels deliberately, maintain active surveillance during early titration Early activation is a common misread Clinical toxicity can occur even when history suggests a "usual dose" Check ammonia if unexplained confusion develops on valproate
Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group.
ECG / QT assessment, Urea, electrolytes, creatinine, Inflammatory markers (CRP/ESR), Creatine kinase
Applies to the Medication Side Effects / Iatrogenic Toxicity / QT Risk group.
None listed
Clinical reference — not validated decision support. Review before use.