Depression due to medical condition

First-onset depression with atypical cognitive/neurological features or systemic context. Look for: Hypothyroidism, Parkinson disease, stroke, Cushing, B12 deficiency, sleep apnoea

UrgentReview due

Compare (7)

At a glance

High-risk causes: 3
Related differentials: 6

Safety snapshot

Watch forLate-life first depressionfocal signsendocrine features

Presentation hinge

Sustained mood syndrome with guilt, hopelessness, reduced energy, impaired concentration, change in sleep/appetite.

Separates the Depression group. It is not specific to Depression due to medical condition.

Clinical review

Rows marked “Whole group”: Applies to the Depression group — not specific to Depression due to medical condition

Why it fits

First-onset depression with atypical cognitive/neurological features or systemic context. Look for: Hypothyroidism, Parkinson disease, stroke, Cushing, B12 deficiency, sleep apnoea

Key features

Must-not-miss

Late-life first depression, focal signs, endocrine features.

High-risk causes3 causes

Late-life first depression
focal signs
endocrine features

Bedside question

Applies to the Depression group.

Sustained mood syndrome with guilt, hopelessness, reduced energy, impaired concentration, change in sleep/appetite.

Helpful clues

Immediate action

Applies to the Depression group.

None listed

Priority steps

Investigations

Applies to the Depression group.

None listed

Core tests

Mimics / overlap

Applies to the Depression group.

None listed

Consider

Clinical reference — not validated decision support. Review before use.